Download the anesthesia central app by Unbound Medicine, 2. ... Nexletol; Ther. Explore these free sample topics: Anesthesia for Vascular Surgery - Abdominal Aortic Repair, -- The first section of this topic is shown below --, Pharm. “Women are half of the population, and nearly 10 million patients in the U.S. with high LDL-C levels are not on statins due to tolerability issues,3 yet these groups have been underrepresented in previous medical research,4” said Ashley Hall, Chief Development Officer for Esperion. References1 Laufs U, et al. NEXLETOL was generally well tolerated, with treatment-emergent adverse events (TEAEs) comparable across the bempedoic acid and placebo groups.1, The poster “Efficacy and Safety of Bempedoic Acid by Sex: Pooled Analyses From Phase 3 Trials” (Abstract #P742) showed NEXLETOL significantly lowered LDL-C at week 12 in both sexes compared with placebo for a pooled population of more than 3,600 patients across four studies. Nursing Central is an award-winning, complete mobile solution for nurses and students. Nexletol is a prescription medicine used along with diet and other lipid-lowering medicines in the treatment of adults with: heterozygous familial hypercholesterolemia (HeFH). DB - Anesthesia Central Any express or implied statements contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. bempedoic acid is a topic covered in the Davis's Drug Guide.. To view the entire topic, please sign in or purchase a subscription.. lipid-lowering agents. Primary research N = 350 healthcare practitioners, 4 J Tamargo, G Rosano, T Walther, J Duarte, A Niessner, JC Kaski, C Ceconi, H Drexel, K Kjeldsen, G Savarese, C Torp-Pedersen, D Atar, BS Lewis, S Agewall, Gender differences in the effects of cardiovascular drugs, European Heart Journal - Cardiovascular Pharmacotherapy, Volume 3, Issue 3, July 2017, Pages 163–182, https://doi.org/10.1093/ehjcvp/pvw042, Contact:Kaitlyn Brosco Esperioninvestorrelations@esperion.com. *Note: Esperion strives to be inclusive in our both research and our language, and we follow the language guidance outlined in “Reporting Sex, Gender, or Both in Clinical Research?” from The Journal of the American Medicine Association (JAMA). bempedoic acid is a topic covered in the Davis's Drug Guide. In these studies, NEXLETOL provided an average of 18% placebo-corrected LDL-C lowering when used with moderate or high-intensity statins. HeFH is an inherited condition that causes high levels of “bad” cholesterol called low density lipoprotein (LDL). The risk for gout events with NEXLETOL® (bempedoic acid) tablet was higher in patients with a prior history of gout although gout also occurred more frequently than placebo in patients treated with NEXLETOL™ (bempedoic acid) tablet who had no prior gout history. Bempedoic acid blocks an enzyme in the liver called adenosine triphosphate citrate lyase, which is involved in making cholesterol. Assess uric acid levels periodically as clinically indicated. Bempedoic Acid [Internet]. Both analyses demonstrated significant lowering of low-density lipoprotein cholesterol (LDL-C) by NEXLETOL® (bempedoic acid) Tablets by week 12 in specific subgroups, including people who cannot tolerate statins and females, compared to placebo. Please Sign in with your Anesthesia Central account, Type your tag names separated by a space and hit enter. Bempedoic acid. Bempedoic acid was generally well tolerated by both sexes.2. NEXLETOL is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C. lipid-lowering agents. Nexletol is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of LDL-C. NEXLETOL is a first-in-class ATP Citrate Lyase (ACL) inhibitor that lowers LDL-C by reducing cholesterol biosynthesis and up-regulating the LDL receptors. Select Try/Buy and follow instructions to begin your free 30-day trial, © 2000–2020 Unbound Medicine, Inc. All rights reserved, TY - ELEC In. Quiring, C., Sanoski, C. A., & Vallerand, A. H. (2020). The most common (incidence ≥ 2% and greater than placebo) adverse reactions were upper respiratory tract infection, muscle spasms, hyperuricemia, back pain, abdominal pain or discomfort, bronchitis, pain in extremity, anemia and elevated liver enzymes. NEXLETOL is the first oral, once-daily, non-statin LDL-C lowering medicine approved in the U.S. in nearly 20 years for patients with ASCVD or HeFH. AU - Sanoski,Cynthia A, Class. - Significant mean reduction of 26.5% in LDL-C with bempedoic acid vs. placebo in pooled analysis of people who cannot tolerate statins1 -, - Analysis by sex showed bempedoic acid significantly lowered LDL-C at week 12 in males and females* vs. placebo2 -. Please see the full Prescribing Information for NEXLETOL by clicking here. Please see important safety information below. This collection of drugs, procedures, and test information is derived from Davis’s Drug, MGH Clinical Anesthesia Procedures, Pocket Guide to Diagnostic Tests, and PRIME Journals. Class. 3 ZS Associates primary and secondary research, Sep-Oct 2018. In: * Article titles in AMA citation format should be in sentence-case, You can cancel anytime within the 30-day trial, or continue using anesthesia central ER -, Quiring, Courtney, et al. NEXLETOL is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with HeFH or established ASCVD who require additional lowering of LDL-C. Visit www.fda.gov/medwatch or call 1-800-FDA-1088 or report side effects to Esperion at 833-377-7633 (833 ESPRMED). Efficacy and Safety of Bempedoic Acid in Patients who Cannot Tolerate Any Does of a Statin: Pooled Analysis from Phase 3 Clinical Trials. Quiring C, Sanoski CA, Vallerand AH. Bempedoic acid. PB - F.A. Presentation at the American Heart Association Virtual Scientific Sessions 2020. UR - https://anesth.unboundmedicine.com/anesthesia/view/Davis-Drug-Guide/110815/0/bempedoic_acid Reporting Sex, Gender, or Both in Clinical Research? Efficacy and Safety of Bempedoic Acid by Sex: Pooled Analyses From Phase 3 Trials. Pharm. DP - Unbound Medicine Nexletol is a first-in-class adenosine triphosphate-citrate lyase (ACL) inhibitor that lowers LDL-C by inhibiting cholesterol synthesis in the liver. Anesthesia Central is an all-in-one web and mobile solution for treating patients before, during, and after surgery. Monitor for signs and symptoms of hyperuricemia, and initiate treatment with urate-lowering drugs as appropriate. For more information, please visit www.esperion.com and follow us on Twitter at www.twitter.com/EsperionInc. 2 Goldberg AC, et al. Forward-looking statements involve risks and uncertainties that could cause Esperion's actual results to differ significantly from those projected, including, without limitation, delays or failures in Esperion’s clinical development and commercialization plans, or approval of expanded indications, that existing cash resources may be used more quickly than anticipated, the impact of COVID-19 on our business, clinical activities and commercial development plans, and the risks detailed in Esperion's filings with the Securities and Exchange Commission. Presentation at the American Heart Association Virtual Scientific Sessions 2020. Pronunciation: bem-pe-doe-ik as-id. Quiring C, Sanoski CA, Vallerand AH. Look up information on diseases, tests, and procedures; then consult the database with 5,000+ drugs or refer to 65,000+ dictionary terms. BT - Davis's Drug Guide Bempedoic acid, sold under the brand name Nexletolamong others, is a medication for the treatment of hypercholesterolemia(high blood cholesterollevels). Through scientific and clinical excellence, and a deep understanding of cholesterol biology, the experienced Lipid Management Team at Esperion is committed to developing new LDL-C lowering medicines that will make a substantial impact on reducing global cardiovascular disease, the leading cause of death around the world. The effect of NEXLETOL on cardiovascular morbidity and mortality has not yet been determined. Discontinue NEXLETOL® (bempedoic acid) tablet at the first sign of tendon rupture. To view the entire topic, please sign in or purchase a subscription. NEXLETOL was approved by the FDA in February 2020. Any forward-looking statements contained in this press release speak only as of the date hereof, and Esperion disclaims any obligation or undertaking to update or revise any forward-looking statements contained in this press release, other than to the extent required by law. Trade Name(s) Nexletol; Ther. NEXLETOL is a first-in-class ATP Citrate Lyase (ACL) inhibitor that lowers LDL-C by reducing cholesterol biosynthesis and up-regulating the LDL receptors. "Bempedoic Acid.". Want to see more products from Unbound Medicine. Avoid NEXLETOL® (bempedoic acid) tablet in patients who have a history of tendon disorders or tendon rupture. ET - 16 © 2020 GlobeNewswire, Inc. All Rights Reserved. to begin a 1-year subscription ($39.95). temporary class adenosine triphosphate-citrate lyase inhibitors-- To view the remaining sections of this topic, please sign in or purchase a subscription--General . Class.temporary class adenosine triphosphate-citrate lyase inhibitors, -- To view the remaining sections of this topic, please sign in or purchase a subscription --. Class. Elevations in serum uric acid have occurred. November 2020. What is Nexletol? The effect of NEXLETOL on cardiovascular morbidity and mortality has not been determined. The approval of NEXLETOL was supported by a global pivotal Phase 3 LDL-C-lowering program conducted in more than 3,000 patients with ASCVD and/or HeFH. Tendon rupture has occurred. Avoid concomitant use of NEXLETOL with simvastatin greater than 20 mg. Avoid concomitant use of NEXLETOL with pravastatin greater than 40 mg. 1. Approved earlier this year by the U.S. Food and Drug Administration (FDA) and launched at the height of the COVID-19 pandemic, NEXLETOL is the first oral, once-daily, non-statin LDL-C-lowering medicine available to indicated patients in nearly 20 years. , & Vallerand, A. H. 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